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OI/CT/PET/SPECT multi-modal image system U-OI/CT/PET/SPECT

Introduction：
MILabs offers arguably the best preclinical imaging platform in the market today. Its individual modalities, whether PET, SPECT, Optical 2D, 3D or 4D Imaging or CT, offer performance and functionality beyond the capabilities of any other small animal imaging system.     Moreover, the platform is fully scalable, including any combination as illustrated above, thus fully exploiting the synergies between modalities by the unique fusion of both hardware and software. Now it is even possible to perform simultaneous acquisitions of multiple co-injected PET and PET/SPECT tracers and Optical Tomography using segmented CT information and perform 3D autoradiography on the same platform.   Now, more than ever, the whole system is greater than the sum of its parts.   

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Adaptive diagnostic CT U-CT

Introduction：
Adaptive diagnostic CT The U-CT system is high-speed and can scan a mouse total body in 5 seconds with ultra low radiation doses, down to less than 2 mGy whole-body. By default, both mice and rats can be imaged. Optionally, the system can be upgraded to image medium size animals, enabling whole-body rabbit imaging. Four performance levels ensure a system configuration that can be adapted to users’ needs. These four performance levels are: Standard E-Class CTSD with reconstructed voxel resolution down to 30 μm, High-Resolution U-CTHR with reconstructed voxel resolution down to 10 μm, Ultra-High Resolution U-CTUHR with reconstructed voxel resolution down to 4 μm, and Extra-Ultra-High Resolution U-CTXUHR with reconstructed voxel resolution down to 2.4 μm using a dedicated ex vivo sample holder.   Optimized for in vivo imaging, the U-CT system features advanced diagnostic capabilities including dynamic contrast-enhanced (DCE) CT imaging using single- or dual-energy scans, ultra-fast fluoroscopic imaging with up to 66 frames per second, DEXA scanning, virtual endoscopy, and cardiac and respiratory gating – sensor-free if desired for simultaneous multi-animal imaging.   Molecular CT upgrades Available as a stand-alone diagnostic CT, the U-CT unit can also be fully integrated with MILabs’ PET, SPECT, and Optical imaging modules. The fusion of these molecular imaging techniques without loss of diagnostic CT capabilities expands applications beyond the reach of other hybrid molecular imaging systems.  

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Stand-Alone Optical Imaging Units U-OI

U-OI

Introduction：
Today MILabs offers the highest flexibility in Optical Imaging. Starting out with a stand-alone system one can add integrated CT, PET and/or SPECT. These unique possibilities provide the flexibility you need for meeting all your research desires. Any integrated combination of Optical, PET, SPECT and X-ray CT is possible, which provides superb synergy across multiple modalities. These high-performance OI units performing bioluminescence, fluorescence and Cherenkov imaging come in 1 Mpx or 4 Mpx. Each unit can be equipped with 6, 12, 24, 36, or 48 emission filters, to fully meet your needs. These systems can be upgraded with CT, PET and SPECT capabilities while maintaining the excellent stand-alone capabilities. The U-OI module features industry-leading ultra-sensitive imaging technology with automatic focus and a computer-controlled filter wheel with narrow band-pass emission filters for multispectral applications. The system features a stage that can accommodate in vivo animal imaging of up to 10 mice as well as ex vivo tissue and micro-well plate imaging.   Integrate with CT for deep-tissue 3D Optical Tomography When combined with integrated U-CT, the system is able to perform 3D/4D Fluorescence Tomography (FLT) and Bioluminescence Tomography (BLT). These optical tomography techniques are of superior quality and the first in the industry using segmented X-ray CT information for the reconstruction of 3D/4D optical images. Integrate with PET and/or SPECT for synergistic multimodal probe imaging Single-pass optical, nuclear and CT imaging facilitates preclinical to clinical translation, and in addition, accelerates multimodal probe development. The combination of imaging multimodal probes within a single session and with a single dose of anesthesia represents in many aspects the new state-of-the-art translational in vivo research.   Exclusive dual-use of MILabs’ Optical Imaging module MILabs Optical Imaging units can be used as stand-alone when placed in the docking station on the bench to image up to 10 mice simultaneously. To perform FLT and BLT, this optical box can be placed on the CT, or Nuclear/CT system. Being able to effortlessly transfer the optical box between the stand-alone bench-top and present modalities and vice versa gives yet another bonus to the MILabs’ optical imaging platforms.  

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Ultra-high-definition focused and whole-body PET U-PET

Introduction：
Ultra-high-definition focused and whole-body PET The U-PET system can perform quantitative 3D functional imaging of PET tracers at < 0.6 mm resolution. This unique and multi-patented system allows for both focused and whole-body imaging of rodents, both in static and dynamic PET modes. The U-PET system is the only one on the market capable of using prompt photons enabling positron-range-free imaging of PET isotopes such as 124I, 76Br, and 82Rb, as well as simultaneous multi-isotope PET imaging of co-injected PET tracers at < 0.75 mm resolution. Because of the innovative detector principle, detection of random photons is completely eliminated and image degradations due to scatter photons are strongly suppressed, resulting in reduced image noise and bias. Excellent image quality can be obtained even with extremely low activities, due to the capability to operate the system at 15% randoms-free sensitivity.   VECTor: simultaneous PET-SPECT The U-PET system is at any time upgradeable with best-in-class SPECT to an integrated PET/SPECT system (“the VECTor platform”), allowing sub-mm imaging of PET and SPECT tracers separately or simultaneously with unprecedented spatial resolutions. The patented SPECT technology offers uniform resolution down to 0.13 mm ex vivo and 0.25 mm in vivo. The stationary detectors of the VECTor allow for fast PET and SPECT imaging in both focused and whole-body modes. It is the only system that can provide PET and SPECT images of co-injected tracers, registered in space and time.   Sub-mm high-energy theranostic imaging. VECTor is the only system on the market suitable for quantitative sub-mm imaging of higher energy radiotherapy and theranostic isotopes such as 131I, 188Re, 213Bi, 225Ac, 223Ra, and many others. This unique combination of advanced technologies earned MILabs the World Molecular Imaging Society (WMIS) 2018 Innovation of the Year award.  

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Ultra-high-resolution SPECT U-SPECT

Introduction：
Ultra-high-resolution SPECT The U-SPECT system can perform quantitative 3D functional imaging of SPECT tracers with proven uniform resolution down to 0.13 mm ex vivo and 0.25 mm in vivo. This unique and multi-patented system allows for extremely fast focused (down to 1 s) and whole-body (down to 8 s) dynamic imaging of rodents. Stationary gamma-ray detectors enable fast temporal resolution, requiring no geometrical re-calibrations. The system can be equipped with a supersensitive collimator that can reach 150,000 cps/MBq or 15% sensitivity with a 20% energy window and then still produces sub-mm resolution images. U-SPECT is upgradeable with High Energy (HE) options and the only system on the market suitable for quantitative sub-mm imaging of higher energy and theranostic isotopes such as 131I, 188Re, 213Bi, 225Ac, 223Ra, and many others.    VECTor: simultaneous PET-SPECT The U-SPECT system is upgradable at any time with ultra-high-definition PET to an integrated PET/SPECT system (“the VECTor platform”), allowing sub-mm imaging of PET and SPECT tracers separately or simultaneously with unprecedented spatial resolutions. Moreover, VECTor is the only system on the market capable of positron-range-free imaging of PET isotopes such as 124I, 76Br, and 82Rb, as well as simultaneous multi-isotope PET and PET/SPECT imaging at < 0.75 mm resolution. This unique combination of advanced technologies earned MILabs the WMIC 2018 Innovation of the Year award.   EXIRAD-3D: Automated Quantitative 3D Autoradiography By scanning cryo-cooled tissue samples, such as complete organs, with a dedicated super-resolution EXIRAD-3D SSPECT option, researchers can finally eliminate many tedious, time-consuming, and error-prone steps from quantitative 3D autoradiography. Thanks to the excellent energy resolving capabilities of the detectors, one can scan multiple isotopes at the same time to image 3D distributions of different molecules simultaneously, at 0.13 mm resolution. EXIRAD-3D images can be re-sliced in any direction, and automatically overlaid with ultra-high resolution X-ray CT images.  

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In Vivo Smoke and Poison Modeling System BKALSPS

Introduction：
A Stable and Efficient Experimental Platform for Animal Models With the advancement of disease research, experimental animal models have become integral to medical studies. However, traditional smoke exposure methods often encounter challenges such as secondhand smoke hazards, uncontrollable smoke concentrations, uneven exposure durations, and inconsistent drug atomization, resulting in low disease modeling success rates, reproducibility issues, and significant consumption of human and material resources.   To overcome these challenges, we introduce a live animal smoke exposure system that offers long-term, stable, and automated smoke fumigation for laboratories. This system is primarily used to establish COPD-related disease models in mice, rats, and guinea pigs, and can also be applied for drug nebulization to facilitate inhalation exposure research and analysis.   Key Features and Benefits: -Innovative Design and User-Friendliness -Floor-mounted integrated design, sleek and user-friendly. -Transparent tempered glass observation port allows for real-time monitoring of animal status. -Integrated monitoring functions for temperature, humidity, oxygen, carbon dioxide, carbon monoxide, and other parameters. -Graphical operation interface for ease of use.   High Automation and Resource Efficiency -Automated smoke poisoning eliminates the need for prolonged experimenter presence. -Remote operation capabilities via mobile devices and other devices save on manpower.   Health and Safety Considerations -Exhaust gas treatment with HEPA high-efficiency filters ensures filtered exhaust and safeguards the cleanliness and safety of both personnel and the environment.   Stability and Efficiency for Improved Success Rates -Stable smoke output, controllable concentration, and uniform exposure time for animal models enhance experimental reproducibility and success rates.  

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