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Machine Intelligent Structured Illumination Microscope HIS-SIM

Introduction：
With its exceptional spatial resolution surpassing 60 nm, swift imaging capabilities reaching up to 1500 frames per second, and an expansive field of view (FOV) of 150 μm with a 100 × objective, the HIS-SIM sets new standards in 3D super-resolution imaging of various dynamic processes in living cells. Notably, MI-SIM's advanced sensitivity and reduced photo-toxicity facilitate prolonged imaging sessions while minimizing photo-bleaching effects.   HIS-SIM boasts a suite of sophisticated features, including real-time super-resolution, multi-camera and multi-site imaging capabilities, and intelligent region-of-interest (ROI) planning. It also excels in stitching within large FOV, 3D real-time tracking, multimodal focusing, and event-driven tracking. These capabilities underscore MI-SIM's versatility, ease of use, and user-centric design, reflecting CSR Biotech's leadership in the realms of advanced imaging, online decision-making, and intelligent control systems.   Highlights 2D/3D Realtime Super Resolution 1st to realize real-time SR imaging, seeing is obtaining Previewing at an 85 nm resolution, our system delivers a clear visualization of mitochondrial inner membrane structures, surpassing the resolution of standard preview methods. It boasts real-time reconstruction speeds of 24 Hz, with the capability to reach up to 65 Hz, facilitating the rapid acquisition of targeted samples for imaging. By bringing super-resolution (SR) imaging into the digital era, we significantly enhance imaging efficiency. This progress allows for quick evaluation of image quality and facilitates the prompt adjustment of regions of interest (ROI) and imaging protocols.   60 nm Super Resolution First to achieve 60 nm resolution in live-cell imaging with extremely low photobleaching Marking a pioneering advancement, our system is the first peer-reviewed technology to attain 60 nm resolution at the living cell level through a blend of optical and computational innovations. It facilitates detailed visualization of every marker and its distribution within living cells, enabling the observation of dynamic structures like the nuclear pore protein NUP98's ring structure, which also has a size of 60 nm.   Long-term Live-cell Tracking World's 1st to realize real-time intelligent tracking for long-term live cell imaging Enhanced Tracking Precision: TRACKER revolutionizes long-term live cell imaging with its advanced ability to automatically adjust for 3D defocus and 2D shifts, ensuring clear focus and tracking accuracy despite cellular motion and morphological changes. Comprehensive Multi-ROl Observation: Designed for detailed analysis, TRACKER adeptly monitors multiple regions of interest (ROIs), capturing crucial morphological and quantitative changes in cell growth, phagocytosis, and division for in-depth, long-term cellular studies.  

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Microscopy for the incubator zenCELL owl

Introduction：
Live cell imaging with the zenCELL owl incubator microscope enables automatization and parallelization of routine and specific cell culture applications. zenCELL owl uses 24 independent cameras to acquire brightfield scans and perform image analysis of up to 24 wells of your cell culture in parallel automatically. The specialized software provides data visualization and analysis in real time and around the clock – 24/7. Culture quality and data can be comfortably checked from your PC – anywhere and anytime without entering the lab. The space-saving and easy-to-handle device is compatible with a range of standard cell culture vessels like multi-well plates, flasks or individual formats.   -Analyze up to 24 wells in parallel -Automize routine applications -Save space & stay flexible -Remote monitoring -Increase data quality & quantity -No user intervention -Automate routine applications   Let zenCELL owl record and analyze your cell cultures: Just set up the experiment and walk away. Check your cell cultures and data analyses anytime from anywhere without going into the lab. Save time for other tasks.   Perform simultaneous cell culture monitoring Analyze cell confluence and morphology of up to 24 wells simultaneously and compare individual wells at the same time to raise the validity and reproducibility of your experiments.   Stay flexible & save space Quickly move or remove the only 18 x 10.5 x 18 cm and 1.05 kg device and leave enough space for other vessels – or further zenCELL owl devices. Benefit from easy cleaning and disinfection and a low-maintenance due to absence of mechanical parts or rust-prone screws. Just plug in the cable, start the intuitive software and get started. No cable clutter in incubator and lab.   Don't miss the smallest detail​ Cell confluence and photos are recorded with a minimum interval of 10 min. 24/7 long term measurement and automated data acquisition increase the validity of your assay by rising the number of tracked and analyzed data points. You never miss a data point due to real-time continuous monitoring. Zoom down to cell level, capture high quality photos or create time-lapse videos. Track and analyze data time-resolved. Analyze dynamic chances and developments of your cell culture retrospectively and in detail.   Let the software do your job Algorithms evaluate the confluence of each picture and estimate changes in the relative cell number objectively and in real time. This creates consistent, reproducible and reliable results with no subjective scope of interpretation. Compare mean values and standard deviations of individually selected wells.   Leave your cells where they belong - in the incubator Your cell cultures and zenCELL owl can remain in the incubator during the complete experiment. Active user interventions are avoided, e.g. for manual microscopy. This prevents fluctuations of the environmental conditions like temperature and CO₂ and lowers the risk of contamination. Measurement results can be clearly traced back to the behavior of the cells at optimal culture conditions. Special settings such as hypoxia can be tested as experiments can be performed under defined conditions.  

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Miniature Two-photon Imaging System TIRM-FPM

Introduction：
The SUPERN0VA-600, our latest flagship product, offers flexible and diverse combination configurations. It allows for the real-time synchronization of microscopic neuronal and synaptic activity with the overall information processing of the brain and individual behaviors, providing a panoramic analysis of connectomes and functional dynamic maps. This technology ensures more efficient, stable, and continuous output of high-quality data, offering researchers an ideal comprehensive imaging solution.   High-quality Data Multiple lasers: 780, 920, 1030 nm High resolution and large FOV Synchronization with animal behaviors in high temporal resolution Integrated and Efficient Multi-color imaging Dual-headpiece dual-color imaging Compatible with optogenetics Full workflow streamlined for multi-modal imaging Stable and Scalable Modular functional design, allowing for easy expansion and upgrades Stable performance under high load operation Remote diagnosis and service available

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Automatic Fluorescence Cell Analyzer Jupita

Introduction：
Jupita is a full-automatic multi-channel cell fluorescence analyzer introduced by Newton Optics. It is based on image detection and combines multi-fluorescence channels to collect cell information in the image for quantitative analysis of cell samples. Jupita combines cell image analysis and counting with fluorescence analysis to provide both bright-field cell counting statistics and analysis results for up to 12 combinations of fluorescence channels.   Patented fully automatic/autofocus cell fluorescence analysis system Jupita adopts Newton optical self-developed automatic cell fluorescence analysis control scheme, and cooperates with stepping motor and joystick to control sample entry, movement and precise positioning, thus realizing multi-channel and multi-field sampling. Jupita can fully automatic focus processing of samples to ensure clear images and accurate results. The design of double laser beam excitation light source and filter turntable greatly improves the stability and operability of the system. Reliable, accurate and fast image processing system Jupita fluorescence analyzer uses industrial-grade high-pixel CMOS, LED excitation light source and filter. In the counting process, each sample is sampled in three fields of view, and the image information of the sample bright field and selected fluorescence channel is collected at the same time. Larger sample collection ensures the accuracy of the count, and it is verified that the fitting R2 value of the count result is greater than 0.999 *. With the integrated control system and efficient algorithm, Jupita cell analyzer can complete the fluorescence analysis of a single field of view in 10 seconds, and the fluorescence analysis results of 6 samples and 18 sampling fields can be obtained in 5 minutes.   Fully automatic multi-fluorescence synchronous detection, a variety of applications at a touch Jupita can provide up to 4 excitation lights and 2 filters to meet the needs of various cell applications. Jupita has a built-in full-automatic optical path switching system. A single experiment can detect the results of 2 channels at the same time. The software presets a variety of commonly used dyes/fluorescent proteins and corresponding spectral combinations for selection. You only need to set up the required experimental scheme and leave the rest to Jupita.

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Cell Counter Zorro

Introduction：
-Independent R & D and production -Based on the classic trypan blue staining exclusion method -Unique LED indicator design -Faster, less expensive, smaller, more accurate, more intuitive -Compatible with multiple cell morphologies and accurate counting -Excellent algorithm automatically filters cell debris and background noise   Cytometer-Zorro (smaller/less/more accurate) Intelligent compact model easy to operate, one step to complete The time to test a sample is only 2s, and a counting plate can be used. Test 6 samples, indicator light design, to ensure the stability of the data;

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Automated Cell Counter Venus

Introduction：
Venus is a full-automatic portable high-throughput cell counter introduced by Newton Optics, which can count all kinds of cells in high-throughput bright field and trypan blue. Venus adopts split design and EasyFive six-digit cell counting plate, which can realize accurate counting of 6 samples and 30 visual fields in one step, and the time is only 1 minute. The unique portable design greatly improves the space utilization of the laboratory.   Patented fully automatic/autofocus cell viability analysis system *  Venus uses Newtonian optical self-developed automatic cell viability analysis control scheme, with stepper motor and joystick control sample entry, movement and precise positioning, the use of high-speed camera to obtain images, combined with analysis software, complete cell count analysis. At the same time, thanks to the inverted microscopic imaging optical path design and compact automatic focusing mobile structure *,Venus has achieved a technological breakthrough of smaller size and higher degree of automation. Fully automated design brings less human factor errors, thereby improving experimental efficiency and accuracy. * A new automatic cell counter. ZL 202020922280.2 (Authorized) * A compact electric focusing moving structure for inverted microscopic imaging. ZL 202021861178.2 (Authorized)   Stable, high-speed, high-throughput image analysis technology  The Venus cell counter uses a high-pixel industrial-grade CMOS sensor. In the counting process, each sample is sampled in 5 fields of view, and the average value is automatically calculated. A larger sample collection volume ensures the accuracy of the count. It is verified that the R2 value of the counting result fitting is greater than 0.999 *. At the same time, with the integrated control system and efficient algorithm, compared with the traditional blood cell counting board manual counting 1 × 106 cells takes about 5 minutes, Venus cell counting instrument only takes 2 seconds. In 1 minute, accurate results * for 6 samples and 30 sampling fields can be obtained *. * Results from cell count tests on RAW264.7,Siha at gradient concentrations, respectively * Results from a single six-sample fully automated test of suspension culture cells at a concentration of 1 × 106   Fully self-developed artificial intelligence algorithm  As the key technology of cell counter, intelligent image recognition and analysis algorithm determines the accuracy and stability of the counting results. Venus cell counter uses Newton optical self-developed artificial intelligence algorithm. After testing and verification, for the same sample, the CV value of single field count is less than 10%, and the CV value of multi-field count is less than 5%. In addition, Newton optics is specially optimized for small diameter, high density, cluster cells, cell debris and other special cell samples, which greatly broadens the scope of application of the cell counter. And, Newton optics will continue to optimize the algorithm design, software free iterative upgrade, suitable for more cell system.  

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Optical Tweezers – Fluorescence & Label-free Microscopy C-Trap G2

Introduction：
The C-Trap® provides the world’s first dynamic single-molecule microscope to allow simultaneous manipulation and visualization of single-molecule interactions in real time. It combines high-resolution optical tweezers, fluorescence, and label-free microscopy, and an advanced microfluidics system in a truly integrated and correlated solution.   How does it work? In 2018 Arthur Ashkin won the Nobel Prize in Physics for his discovery that the momentum of light can be used as an incredibly sensitive set of “tweezers”. By shooting a laser through a microscope, he created a highly focused beam of light strong enough to trap and hold in place objects such as plastic beads. These beads can be coated to stick to a variety of biomolecules, such as proteins, cytoskeleton filaments, DNA, or RNA. Furthermore, the tiniest forces applied to these molecules can be measured as well, giving the world access to a tool not only capable of manipulating biomolecules but also capable of detecting what’s happening to them.   How can it be applied to my research? Whether you are aiming to make novel discoveries in the life sciences or develop successful drug candidates, we work on a personal level to find the right solution for you. Browse our extended list of applications to discover how these technologies can benefit your research.   -Stable and precise sample manipulation Different optical tweezers configurations and advanced manipulation features allow you to get the most out of your sample.   -A wide variety of visualization capabilities Choose and combine from a variety of imaging methods designed specifically to solve the needs of different experimental designs.   -Introducing the new C-Trap products Dymo & Edge With the desire to constantly produce breakthrough discoveries, you need an easy-to-use instrument, fully-optimized for your applications that should bring unprecedented insights with high precision, accuracy, and reliability, in short time. Discover your solutions below!   -High throughput experiment workflow Loading your sample and analysing your data in less than 30 minutes.   -Easy and intuitive software package Check how you can completely automate your experiments using our user-centered software workflow, experience seamless process from data collection to data analysis.

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Optical Tweezers m-Trap

Introduction：
The m-Trap is the first entry-level optical tweezers instrument specifically developed for high-resolution single-molecule research. Ultra-high force resolution and stability, with incredible throughput, ease of use, and modularity – all at an unprecedented price level.   How does it work? In 2018 Arthur Ashkin won the Nobel Prize in Physics for his discovery that the momentum of light can be used as an incredibly sensitive set of “tweezers”. By shooting a laser through a microscope, he created a highly focused beam of light strong enough to trap and hold in place objects such as plastic beads. These beads can be coated to stick to a variety of biomolecules, such as proteins, cytoskeleton filaments, DNA, or RNA. Furthermore, the tiniest forces applied to these molecules can be measured as well, giving the world access to a tool not only capable of manipulating biomolecules but also capable of detecting what’s happening to them.   How can it be applied to my research? Whether you are aiming to make novel discoveries in the life sciences or develop successful drug candidates, we work on a personal level to find the right solution for you. Browse our extended list of applications to discover how these technologies can benefit your research. Don’t see your specific field represented? Drop us an e-mail to see what we can do!   -Stable and precise sample manipulation Advanced manipulation features that allow you to get the most out of your sample. Fully supported integration and correlation with custom optical layout allowing for 3rd party system integration.   -High throughput experiment workflow Loading your sample and analysing your data in less than 30 minutes.   -Easy and intuitive software package Check how you can completely automate your experiments using our user-centered software workflow.

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Inverted Fluorescence Microscope B80iFV

Introduction：
The B80iFV digital inverted fluorescence biological microscope adopts an excellent infinite distance optical system. Equipped with a long working distance flat field objective and an integrated LCD screen, the compact and stable high rigidity body fully meets the anti vibration requirements of microscopic operations.   The transmission optical axis that can be adjusted at a 45 ° angle facilitates the observation of stained culture cells in culture dishes or cylindrical flasks, providing greater operating space.   This instrument is suitable for microscopic observation of cellular tissues, transparent liquid tissues, and dynamic microscopic observation of cultured tissues in culture dishes.   The product can be widely used in fields such as biology, medicine, industry, agriculture, etc.

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Inverted Fluorescence Microscope B80iF

Introduction：
The B80iF inverted biological microscope adopts an excellent infinite distance optical system. Equipped with a long working distance flat field objective and a large field of view eyepiece, a compact and stable high rigidity main body fully meets the anti vibration requirements of microscopic operations.   The transmission optical axis that can be adjusted at a 45 ° angle facilitates the observation of stained culture cells in culture dishes or cylindrical flasks, providing greater operating space.   This instrument is suitable for microscopic observation of cellular tissues, transparent liquid tissues, and dynamic microscopic observation of cultured tissues in culture dishes.   The product can be widely used in fields such as biology, medicine, industry, agriculture, etc.

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Inverted Microscope B60iV

Introduction：
The B60iV digital inverted biological microscope adopts an excellent infinite distance optical system. Equipped with a long working distance flat field objective and a large LCD screen, the compact and stable high rigidity body fully meets the shock resistance requirements of microscopic operations.   The transmission optical axis that can be adjusted at a 45 ° angle facilitates the observation of stained culture cells in culture dishes or cylindrical flasks, providing greater operating space.   This instrument is suitable for microscopic observation of cellular tissues, transparent liquid tissues, and dynamic microscopic observation of cultured tissues in culture dishes.  

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Inverted Microscope B60iL

Introduction：
The B60iL inverted biological microscope adopts an excellent infinite distance optical system. Equipped with a long working distance flat field objective and a large field of view eyepiece, a compact and stable high rigidity body fully meets the shock resistance requirements of microscopic operations.   A transmission optical axis that can be adjusted at a 45 ° angle, specifically designed for observation in cell factories with a long transmission optical axis, meets the working requirements of multi-layer cell factories and provides greater operating space.   This instrument is suitable for microscopic observation of cellular tissues, transparent liquid tissues, and dynamic microscopic observation of cultured tissues in culture dishes.   The product can be widely used in fields such as biology, medicine, industry, agriculture, etc.

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Inverted Microscope B60i

Introduction：
The B60i inverted biological microscope adopts an excellent infinite distance optical system. Equipped with a long working distance flat field objective and a large field of view eyepiece, a compact and stable high rigidity body fully meets the shock resistance requirements of microscopic operations.   The transmission optical axis that can be adjusted at a 45 ° angle facilitates the observation of stained culture cells in culture dishes or cylindrical flasks, providing greater operating space.   This instrument is suitable for microscopic observation of cellular tissues, transparent liquid tissues, and dynamic microscopic observation of cultured tissues in culture dishes.    

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Inverted Microscope B50i

Introduction：
The B50i inverted biological microscope adopts an excellent infinite distance optical system, which can provide excellent optical performance.   The streamlined design concept and compact and stable high rigidity main body fully meet the seismic requirements of microscopic operations.   The long working distance spotlight system can observe cells in culture dishes or cylindrical flasks without contamination. The lighting system fully considers heat dissipation and safety, and the human-machine engineering design concept makes operation more convenient, comfortable, and safe.   This instrument can be used for microscopic observation of cellular tissues, transparent liquid tissues, and dynamic microscopic observation of cultured tissues in culture dishes. The product can be widely used in fields such as biology, medicine, industry, and agriculture.

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Upright Fluorescence Microscope B80F

Introduction：
The B80F upright fluorescence biological microscope is widely used for microscopic observation purposes in industries, agriculture, medical and health, laboratories, school teaching, and life science research fields.   The B80F upright fluorescence biological microscope infinite far beam system is composed of high-end optical devices, which have the characteristics of long working distance, strong color difference correction ability, and high sensitivity fluorescence imaging. Designed ergonomically to reduce muscle tension and fatigue caused by repetitive work.   B80F focuses on every detail, detecting, analyzing, and researching with advanced digital cameras and intelligent software, which is sufficient to meet various application needs. Easy to operate, fast signal acquisition speed, high efficiency, and reliable performance.   The B80F fluorescence module is a turntable switch, with the light source and filter block linked for easy operation; Up to 5 custom channels can be configured, and the updated coating technology of the filter ensures high fluorescence intensity with high transparency, while also providing excellent quality and consistency to avoid pixel drift. Coupled with a high sensitivity camera, the excellent stretchability can meet the high-quality fluorescence imaging needs of various probe labels.

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Upright Fluorescence Microscope B70F

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The B70F upright fluorescence microscope is widely used for microscopic observation in industries, agriculture, healthcare, laboratories, school teaching, and life science research fields.   The B70F upright fluorescence microscope focuses on every detail, is easy to operate, and is equipped with an imaging system that has fast signal acquisition speed, high efficiency, and reliable performance.   The B70F features LED lighting with constant color temperature or frequency bands, high-end optical components, and an infinite high beam path system, providing you with high-definition, high sensitivity, and excellent results.   The update of B70F fluorescent filter in coating technology ensures high fluorescence intensity with high transparency, while also providing excellent quality and consistency, avoiding pixel drift. Combined with high sensitivity cameras, it can meet the high-quality fluorescence imaging needs of various probe labels.

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Upright Fluorescence Microscope B60F

Introduction：
The B60F upright fluorescent biological microscope adopts an infinite far-field achromatic fluorescent objective and a large field of view eyepiece, with clear optical system imaging and a wide field of view.   The excitation light source adopts a high-power and high brightness monochromatic LED module group, and the transmission light source adopts a high-power and high brightness white LED module. The lighting brightness is adjustable, the lighting device has low power consumption, long service life, and safe and comfortable operating performance.   The product can be widely used in fields such as biology, medicine, industry, agriculture, etc.

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Upright Microscope B80

Introduction：
The B80 upright biological microscope is widely used for microscopic observation in industries, agriculture, healthcare, laboratories, school teaching, and life science research fields. The B80 upright biological microscope infinite far beam system is composed of high-end optical devices, which have the characteristics of long working distance, strong color difference correction ability, and high sensitivity fluorescence imaging. Designed ergonomically to reduce muscle tension and fatigue caused by repetitive work. B80 focuses on every detail, detecting, analyzing, and researching with advanced digital cameras and intelligent software, which is sufficient to meet various application needs. Easy to operate, fast signal acquisition speed, high efficiency, and reliable performance.

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Upright Microscope B70

Introduction：
The B70 upright biological microscope is widely used for microscopic observation in industries, agriculture, healthcare, laboratories, school teaching, and life science research fields. The B70 upright biological microscope focuses on every detail, is easy to operate, and is equipped with an imaging system that has fast signal acquisition speed, high efficiency, and reliable performance.

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Upright Microscope B60

Introduction：
The B60 upright biological microscope is equipped with an infinite far-field achromatic objective and a large field of view eyepiece, providing clear imaging and a wide field of view. Ideal design that meets ergonomic requirements, featuring a low level focusing handwheel, inward facing objective converter, and built-in handle design, making operation more convenient and comfortable.   -The product can be widely used in fields such as biology, medicine, industry, agriculture, etc. -Adopting excellent infinite optical systems, it can provide excellent optical performance. -The compact and stable high rigidity body fully embodies the anti vibration requirements of microscopic operations. -Ideal design that meets ergonomic requirements, making operation more convenient and comfortable, and providing a wider space. -Mechanical mobile loading platform, suitable for microscopic observation or rapid detection of multiple samples. -Modular functional design can facilitate system upgrades and achieve functions such as phase contrast observation.

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Upright Microscope B50

Introduction：
The B50 upright biological microscope is equipped with a flat field achromatic objective and a large field eyepiece, providing clear imaging and a wide field of view. Adopting a smooth and concise exterior design, the low position focusing handwheel and inward facing objective converter make operation convenient and comfortable. The product can be widely used in fields such as biology, medicine, industry, agriculture, etc.

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Stereo Microscope S80

Introduction：
● Adopting a parallel optical system, the main body has a continuous zoom range of 0.8X~8X; ● Continuous zoom from high to low magnification, clear and flicker free throughout the entire process, large depth of field, long working distance, and abundant accessories; ● Widely used for high-precision requirements in scientific research, biology, medicine, environment, agriculture and forestry, public security, microelectronics, semiconductors, and other fields.

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Stereo Microscope S70

Introduction：
● Design using patented technology; ● Long working distance, large depth of field, and large zoom ratio; ● The three camera host can be connected to CCD (CMOS) cameras and digital cameras; ● Multiple magnification eyepieces, dividing eyepieces, and large objective lenses are available for selection; ● Can be equipped with various bases and universal brackets, LED ring lights, ring fluorescent lights, fiber optic and other lighting options; ● Widely used in schools, biotechnology and scientific research, industrial assembly, testing and measurement, and quality control.  

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Stereo Microscope S65

Introduction：
● Full focus with clear and no flicker throughout the entire process; ● New optical design, reproducing the best resolution and true color images; ● Large depth of field, wide field of view, ultra long working distance, and high cost-effectiveness; ● Meet the high-precision requirements of modern biological research, semiconductors, and other technological industries.

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Stereo Microscope S45

Introduction：
● Full focus with clear and no flicker throughout the entire process; ● New optical design, reproducing the best resolution and true color images; ● Large depth of field, wide field of view, ultra long working distance, and high cost-effectiveness; ● Meet the high-precision requirements of modern biological research, semiconductors, and other technological industries.

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