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Flow Cytometry Cell Analyzer Ze5

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The ZE5 Cell Analyzer is an innovative, versatile flow cytometer designed to deliver powerful advancements in the quality and quantity of data that you can generate. It is versatile enough to handle complex assays and able to deliver data at a rate unmatched by other instruments. Versatile   The ZE5 Cell Analyzer has a host of attributes that make it perfect for a wide range of applications and workflows: -Allows complex immunophenotyping with up to 5 lasers and 30 detection parameters -Adapts to your workflow, with a universal sample loader that can accommodate a wide range of sample formats and has integrated vortexing and temperature control -Powers through high throughput and screening assays with fast plate handling, allowing 96-well plates to be completed in less than 15 minutes and 384-well plates in less than 60 minutes -Detects rare events faster with an acquisition rate of up to 100,000 events/second without losing data due to electronic aborts -Resolves small particles, including exosomes, with a dedicated small particle detector -Performs advanced analysis with FCS Express analysis software   Easy to Use Designed for busy multi-user laboratories and with an emphasis on ease of use, it incorporates innovative features that make it ideal for users with any level of experience: -Learn, use, and train with ease with intuitive software and a unique experiment builder wizard -Fluidics that never run dry with dry sample detection and live sheath and waste tank monitoring -Self-cleaning with on-board cleaner -QC at the touch of a button with on-board QC beads   Automation and 21 CFR Part 11 Ready If you are considering flow cytometry for high throughput screening or pre-clinical applications that require 21 CFR Part 11 compliance, the ZE5 Cell Analyzer is an ideal choice. -Designed to allow easy integration into robotic workcells -Hands-off operation with optional large capacity fluidics -Widely compatible with new or existing robotic workcells with a hardware and software agnostic application programming interface (API) -Data acquisition with 21 CFR Part 11 support using Xybion Compliance Builder software -Advanced data analysis with 21 CFR Part 11 support with FCS express analysis software (contact support@denovosoftware.com for more information) -IQ/OQ service available           

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Automated Cell Imaging System ImageXpress Pico

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Digital microscopy with automated brightfield, fluorescence, and Digital Confocal imaging The ImageXpress® Pico Automated Cell Imaging System is more than a digital microscope, combining high-resolution imaging with powerful analysis. Whether running fluorescence imaging or brightfield assays, the automated imager features a comprehensive portfolio of preconfigured protocols for cell-based assays to shorten the learning curve, so you can start running experiments quickly. With features such as Digital Confocal* 2D on-the-fly deconvolution, Autofocus, Live Preview, multi-wavelength cell scoring, and optional IN Carta® Image Analysis Software workflow, the ImageXpress Pico offers you the ability to advance your discoveries in a small, affordable imager.   Get started quickly With the icon-driven, user-friendly CellReporterXpress® Image Acquisition and Analysis Software, your entire lab can streamline their digital microscopy. Start capturing and analyzing images with minimal training.   Do more than cell counting Expand your assays with over 25 preconfigured templates optimized for many cell-based experiments including apoptosis, mitochondrial evaluation, 3D cell models, live cell/timelapse, multiwavelength cell scoring, and neurite tracing.   Automate imaging affordably Alleviate the hassle of going to the core lab to run your samples. The system’s lab-friendly price allows researchers to afford the convenience of automated imaging and analysis on their lab bench. With options like Digital Confocal, environmental control and z-stack acquisition, the system can be ordered to fit your research.   Multiple imaging modes The ImageXpress Pico system offers objectives ranging from 4x to 63x and can operate in colorimetric, brightfield, fluorescence, or Digital Confocal 2D on-the-fly deconvolution imaging modes.   Preconfigured analysis protocols Over 25 preconfigured analysis protocols ranging from simple cell counting to sophisticated neurite tracing analysis. With features like the click-to-find tool, analysis parameters can be optimized by simply clicking on a few cells that match specific criteria.   Plate-to-individual cell view Data can be visualized at multiple levels from plate overview to individual cells. A wide variety of data visualization tools from the plate and cellular level empower users to learn as much as possible from their images and assays.   Z-stack acquisition Generate sharper images for more accurate segmentation using z-stack acquisition. Acquire a series of images at different focal points to capture more detail than with a single slice. Users can include all slices or select which slices to include in the final projection.   Quickly and easily identify regions of interest Live Preview simplifies identification of regions of interest, letting users pan around the sample and interactively adjust focus with a virtual joystick, saving time and effort.   Environmental control Multi-day, time lapse, and live cell assays can be run using the onboard environmental system with options for humidity, CO2, and O2 control. Optimized to prevent z-drift, the software also provides real-time monitoring of environmental state, ensuring optimal assay conditions.  

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Automated Imaging System ImageXpress Nano

Introduction：
Fluorescence imaging platform within reach of every lab The ImageXpress® Nano Automated Imaging System features a long life, solid state, light engine, and optics to reliably deliver the right assay sensitivity. Capture fine details of a variety of cellular and subcellular assays with this powerful and flexible fluorescent microscopy solution. The system includes MetaXpress® High-Content Image Acquisition and Analysis Software with tools for 2D and 3D imaging and time lapse analysis, as well as a range of needs from ease-of-use through to proprietary assay design.   Image label-free Brightfield imaging allows for rapid acquisition without the use of harmful fluorescent agents.   Streamline image analysis The modular toolbox in the MetaXpress® software allows for the quick setup of hundreds of routine assays. Choose from our optional selection of turnkey application modules for greater convenience.   Capture a diverse range of samples With 2x to 60x magnification, the system offers the flexibility to image whole-well (C. elegans, zebrafish), as well as sub-cellular details (vesicles, organelles).   Large field of view An entire well of a 384-well plate can be captured in a single image at 4x magnification for faster throughput.   Automated Stages Fully automated X, Y, and Z stages with resolution better than 25 nm.   Wide range of filters and objectives The system can be configured with different filters or objectives (2-60x) to meet research needs.   Five fluorescent channels The system can have up to 5 fluorescent filters installed at one time. The software allows up to 7 channels to be acquired at one time which enables multi-channel fluorescent and transmitted light imaging in one experiment.   High-speed autofocus Laser autofocus enables quick, consistent focusing across plates, slides and uneven surfaces.   Environmental control option Multi-day, time lapse and live cell assays can be run using the onboard environmental system with options for temprature, humidity, and CO2 control.  

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High-Content Imaging System ImageXpress Micro 4

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Widefield imaging for basic research through to high-content screening The ImageXpress® Micro 4 High-Content Imaging System is a high-throughput, widefield imager that can acquire images of whole organisms and cellular or intracellular events. It features proprietary fast frame rate technology, allowing for the capture of fast biological processes such as calcium oscillations in cardiomyocytes. It is highly configurable and adaptable to changing research needs. Available options include confocal, brightfield, phase contrast, liquid handing, and environmental control.   Support many cellular assays Image an incredible range of assays with various user-changeable filter cubes, 1-100x objectives, environmental control, fluidics option, and many sample formats including atypical plates for 3D assays.   Analyze images of more applications A selection of feature-rich turnkey application modules is available with MetaXpress® software. For the development of novel assays, we offer an optional custom analysis module.   Tailor the system to meet your needs The imager is a highly flexible solution, you can add or change many of the components as your research priorities change. Examples include enhance light engines and automation.   Multiple imaging modes The system offers fluorescence, widefield, colorimetric, phase contrast, and brightfield label-free imaging.   Upgradeable to confocal The system can be upgraded to include the proprietary AgileOptix™ technology for accurate 3D volumetric analyses.   Wide dynamic range Low and high intensity signal quantification in a single image with >3 log dynamic range intensity detection.   High speed image acquisition Using 4x magnification with a 1536-well plate, 225K wells per day can be acquired. Greater than a million wells per week can be imaged.   Optional environmental control Temperature, humidity, and CO2 control for multi-day live-cell imaging or fast kinetic studies are available.   Large magnification range Air and oil immersion objectives ranging from 1x to 100x are available for installation into the 4-position objective changer.    

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High-Content Imaging System ImageXpress Micro Confocal

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High-content confocal imaging solution with water objective options The ImageXpress® Micro Confocal system is a high-content solution that can switch between widefield and confocal imaging of fixed and live cells. It can capture high quality images of whole organisms, thick tissues, 2D and 3D models, and cellular or intracellular events. The spinning disk confocal and sCMOS camera enable imaging of fast and rare events like cardiac cell beating and stem cell differentiation. With MetaXpress software and flexible options like water immersion objectives to choose from, the system enables many confocal imaging applications from 3D assay development to screening.   Acquire higher quality images Capture excellent contrast, high resolution images with our proprietary AgileOptix™ spinning disk confocal technology, wide field of view, and bright light source.   Customize image acquisition and analysis Take ultimate control over acquisition and analysis parameters, which enables many applications from 3D structure analysis to target imaging of specific objects within an organism or cell populations. Run more applications with standard options like water immersion objectives, environmental control, or any of our high-performance customizations.   Analyze more data in less time MetaXpress® PowerCore™ software accelerates analysis speed in a high-throughput environment. The software distributes image processing jobs to a multi-CPU environment.   Wide dynamic range Quantify low and high intensity signals in a single image with >3 log dynamic range intensity detection.   Exclusive AgileOptix spinning disk confocal The technology provides increased sensitivity with specially designed optics, high-powered, solid state light engines, and sCMOS sensor. Swappable disc geometries provide flexibility between speed and resolution.   Wide field of view Wide field of view enables whole-well confocal imaging and eliminates missed targets.   Optional on-board robotic fluidics For assays that involve compound addition, well washing, and media exchange, optional on-board robotic fluidics are available.   Accurate 3D measurements MetaXpress 3D analysis module is optimized for confocal imaging, enabling 3D measurements of volume and distance.   Multiple imaging modes The system offers phase contrast and brightfield label-free imaging, fluorescence, widefield, colorimetric, and confocal imaging, as well as, water immersion imaging as a standard option.  

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High-Content Imaging System ImageXpress Confocol HT.ai

Introduction：
Capture large 3D organoid and spheroid images with up to double the speed The ImageXpress® Confocal HT.ai High-Content Imaging System utilizes a seven-channel laser light source with eight imaging channels to enable highly multiplexed assays while maintaining high throughput by using shortened exposure times. Water immersion objectives improve image resolution and minimize aberrations so scientists can see deeper into thick samples. The powerful combination of MetaXpress® software and IN Carta® software simplifies workflows for advanced phenotypic classification and 3D image analysis with machine learning capabilities and an intuitive user interface.   Enable greater assay flexibility Eight imaging channels with laser excitation enable more assay flexibility, higher image brightness, and flexibility to use targeted imaging such as QuickID. Automated Water Immersion objectives offer greater numerical aperture and matched refractive index between the sample and the immersion media for enhanced resolution and decreased aberrations.   Increase throughput with higher quality images Higher excitation power provides increased signal, shorter exposure times, and faster acquisitions of 3D samples. Micro-lens enhanced spinning disk confocal provides a flat field of view for more accurate and reproducible image analysis. Shorter exposure times generates up to a two-fold boost in scan speed. FRET experiments using lasers for CFP and YFP expand research.   Accelerate analysis speeds IN Carta Image Analysis Software performs complex segmentation and classification. Phenoglyphs provides a robust trainable classification, and SINAP provides trainable segmentation for any image type. Accelerate analysis speeds by 40X with multi-threaded, parallel processing with MetaXpress® PowerCore Software. Reduces time from hours to minutes, eliminating 3D analysis as a bottleneck.   High-intensity laser light source Capture images faster with shorter exposure times. Multiplex your experiments with 7 lasers and 8 imaging channels.   Accurate 3D measurements Custom Module Editor 3D analysis is optimized for confocal imaging, enabling 3D measurements of volume and distance.   Wide field of view Wide field of view enables whole-well confocal imaging and eliminates missed targets. Next-generation dual microlens enhanced spinning disk technology provides a large, flat field of view for more accurate and reproducible analysis.   Exclusive AgileOptix™ spinning disk technology Provides increased sensitivity with specially designed optics, high-powered laser illumination, and sCMOS sensor. Swappable disk geometries provide flexibility between speed and resolution.   IN Carta Image Analysis Software Leverages machine learning to improve the accuracy and robustness of high-content image analysis, delivering data insights that other technologies miss. Reduces the complexity of image analysis with intuitive guided workflows in a modern user interface.   Multiple imaging modes The system offers phase contrast and brightfield label-free imaging, widefield and confocal fluorescent imaging with water immersion optics as a standard option.   Automated water immersion objective technology Offers greater image resolution and sensitivity with up to 4x increase in signal leading to lower exposure times.   Wide dynamic range Quantifies low and high intensity signals in a single image with >3 log dynamic range intensity detection.    

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High-Throughput Cellular Screening System FLIPR Penta

Introduction：
An industry-renowned instrument for monitoring GPCRs and ion channels Powered by a new, optional high-speed EMCCD camera and the new Peak Pro 2 software module, the new FLIPR® Penta High-Throughput Cellular Screening System allows you to measure and analyze peaks of human-derived induced pluripotent stem cells (hiPSCs), differentiated into cardiomyocytes and neurons, up to 100 times per second and quickly cherry pick events such as Early Afterdepolarization-like events (EAD-like events), fibrillation, and irregular beating. Since its introduction, the system has developed a reputation for reliability and ease of use. The system can be configured based on library size, detection mode, screening format, assay, and target, making the transition from assay development to lead optimization a seamless process.   Assess toxicity effects The HS-EMCCD camera option allows for up to 100 measurements per second, providing detailed information about cardiomyocyte and/or neuronal oscillation. Combined with the ScreenWorks® Peak Pro 2 software analysis module, compound-induced pro-arrhythmic effects such as EAD-like events can be easily identified and flagged.   Identify lead compounds With seven LED sets, many filter options, and fluorescence or luminescence detection, the FLIPR system supports many assays, including calcium flux, potassium, and membrane potential.   Configure to your throughput The FLIPR Penta system can be configured to match user needs. From manual assays to automated solutions, to measuring 96-, 384-, or 1536-well samples at a time, to using wash or no-wash assay kits in adherent mode, the system can be upgraded as needs change in the future.   Complex event analysis ScreenWorks Peak Pro 2 software analysis, powered by pCLAMP 11, gives you the unique ability to characterize calcium oscillation peak data in one software program. Compounds can be flagged that cause waveform irregularities that may indicate hazards for arrhythmia, seizures, or other toxicity effects quickly and without having to export data. Distinctly different calcium oscillations in neurons can also be characterized.   Configurable optics The FLIPR Penta system can be matched to user needs starting with a standard EMCCD camera, a more cost-effective solution that is perfect for GPCR and Membrane Potential assays, or with the new HS EMCCD that can capture up to 100 images per second and offers exceptional luminescence performance. The camera, LEDs, and filters can be configured at the time of purchase or later when assay needs change.   User-changeable pipette modules Pipette heads can be changed in minutes without the use of tools from 96, 384, or 1536 channels to accommodate assay throughput needs.   Ease of use ScreenWorks software seamlessly incorporates drag-and-drop protocols, intuitive buttons, and color-coded plate layout to simplify workflows. View signal traces, EC50 curves, and Z factors on-the-fly without having to export data to another software program.   Validated solution Purchasing a FLIPR system from Molecular Devices assures users that they are investing in a technology that can grow with them. Hardware, software, and assay kits have been validated on the system by an industry-renowned leader with over 40 years of experience.   Custom automation options* The drug discovery process has shared methods, yet each project is unique. The Advanced Workflow Engineering Solutions Team offers a variety of customized services from automated compound plate delivery to fully integrated workstations with automated incubation.    

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Electroporation System Gemini X2

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The Gemini Twin Wave Electroporators are flexible systems allowing both square wave and exponential decay wave electroporation in a single unit. Ideal for all of your electroporation needs, including CRISPR, in vivo, in vitro, in ovo and more. Systems for cuvettes or plates. These waveform combinations enable researchers to easily and efficiently electroporate eukaryotic and prokaryotic cells in cuvettes or plates with one easy-to-use setup. Prokaryotic cells typically respond well to exponential decay wave pulses and eukaryotic cells are transfected most efficiently with square wave pulses. Combining these two waveforms gives researchers total flexibility to achieve the highest efficiency for their applications.   FEATURES & BENEFITS -Square wave and exponential decay waves power in a single unit -Multiple pulsing capabilities in both square and exponential decay waveforms (X2 systems) -Large 7-inch, easy-to-use touch screen interface -Universal electroporation – transfects cells in vitro, in vivo, in ovo and adherent forms -Preset protocols – includes the most common eukaryotic and prokaryotic cell types -User-defined protocols – unlimited ability to add and modify protocols -Safety – displays resistance measurements for each pulse with three layers of arc protection -Data management – stores logs of every pulse delivered for QC and troubleshooting  

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Electroporation System Gemini SC

Introduction：
The Gemini Twin Wave Electroporators are flexible systems allowing both square wave and exponential decay wave electroporation in a single unit. Ideal for all of your electroporation needs, including CRISPR, in vivo, in vitro, in ovo and more. Systems for cuvettes or plates. These waveform combinations enable researchers to easily and efficiently electroporate eukaryotic and prokaryotic cells in cuvettes or plates with one easy-to-use setup. Prokaryotic cells typically respond well to exponential decay wave pulses and eukaryotic cells are transfected most efficiently with square wave pulses. Combining these two waveforms gives researchers total flexibility to achieve the highest efficiency for their applications.   FEATURES & BENEFITS -Square wave and exponential decay waves power in a single unit -Multiple pulsing capabilities in both square and exponential decay waveforms (X2 systems) -Large 7-inch, easy-to-use touch screen interface -Universal electroporation – transfects cells in vitro, in vivo, in ovo and adherent forms -Preset protocols – includes the most common eukaryotic and prokaryotic cell types -User-defined protocols – unlimited ability to add and modify protocols -Safety – displays resistance measurements for each pulse with three layers of arc protection -Data management – stores logs of every pulse delivered for QC and troubleshooting  

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Electroporation System Agile Pulse™ In Vivo

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The AgilePulse In Vivo System, used for animal immunization, vaccine development, and gene therapy, provides an intra-muscular, intra-dermal, or intra-tumor electroporation solution to produce maximum transfection efficiency. Traditional in vivo nucleic acid delivery systems, such as gene gun delivery, suffer from poor efficiency. The AgilePulse In Vivo System effectively introduces DNA or RNA into the target tissue, representing a powerful and safe means for stimulating an immune response that recognizes and eliminates target molecules in the body. For vaccine applications, DNA vaccination through the dermal layer is preferred since it is an easily accessible site that is immunologically active. After direct injection of plasmid DNA in the dermal layer, a programmed sequence of electric pulses is applied through a miniature parallel needle electrode array to promote cellular uptake and transfection. Cells in the surrounding tissue are transfected, including dendritic antigen-presenting cells and mesenchymal origin cells. Gene expression simulates the immune system to respond to the secreted antigen. Gene expression in skin is 100-fold higher when delivery is enhanced by electroporation compared to simply injecting plasmid DNA (Roos, et. al. 2009). Features -Simple User Interface—touch screen user interface, USB key data storage, and Windows® Mobile 6.0 operating system. The system automatically stores a digitized record of all pulse parameters for quality control. EN 60601-1, EN 60601-1-1 EN 60601-1-2, UL60601-1 and CSA601.1 compliant. -Pulse Agile® Advantage—patented Pulse Agile technology combines a unique sequence of short, high-intensity pulses to open pores in cell membranes, followed by long, low-intensity pulses to further drive the DNA into cells via electrophoresis. The adjustable pulses improve efficiency while maintaining cell viability. The specialized use of the Pulse Agile waveform has shown to significantly enhance antigen specific CD8+ T-cell response when standard protocols do not. -Uniform, Reliable Electroporation—AgilePulse parallel-needle arrays produce uniform electric fields across the treatment area for a more thorough transfection of the tissue. Electrode impedance is monitored through software analysis to ensure reliable electrode placement in tissue each and every time. -Simple, Fast Treatment—simple yet effective intra-dermal or intramuscular electrode design allows for shorter delivery times of less than a second. The electrodes provide a uniform pulse to cover and target larger areas of tissue using a single pulsing application. -Optimal Design—miniature, 2-mm length needles easily penetrate the layers of skin or muscle and target cells for high efficiency gene delivery. -Safety—Each needle electrode array comes with a safety cover and easy grip sides to make the electrode insertion procedure simple and safe.

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Electroporation System Agile Pulse™ MAX

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The AgilePulse MAX System is an advanced electroporation solution for fast, efficient transfection of up to 10 ml of cell suspension. Specifically engineered for large-volume applications, our system maximizes cellular uptake with minimal heating and short cycle-time to ensure high cell viability in further cell processing.   The AgilePulse MAX System is simple to use. Cells and polynucleotide are suspended in our proprietary BTXpress Cytoporation Medium T or Cytoporation Medium T4 and transferred via sterile syringe to the large volume electroporation chamber where a programmed sequence of electric pulses is applied. First, a sequence of short, high-intensity pulses opens pores in the cell membranes. These are followed by long, low-intensity pulses that drive the material into cells via electrophoresis. Our patented PulseAgile technology optimizes these pulse parameters to maximize efficiency and cell viability.   The system includes a user-friendly, programmable waveform generator with patented PulseAgile technology, our patent-pending large-volume electroporation chamber, and proprietary BTXpress Cytoporation Medium T, optimized for large volume electroporation. The system is engineered to provide uniform electric fields in a stable temperature environment for excellent cell viability.   Features -Scale-up—transfection protocols readily scale-up from standard laboratory cuvettes to large-volume transfection in the AgilePulse MAX system.   -Maximal Efficiency with Cytoporation Medium—BTXpress Cytoporation Medium T used with the AgilePulse MAX system has been optimized for maximal efficiency with a number of cell lines, including K562, A20, HEK293 and CHO-KI. It is compatible with a large range of transfectants including DNA, RNA, siRNA, and olignonucleotides. It can be directly diluted in complete growth medium for post-electroporation cell culture.   -Simple User Interface—all controls are operated with the simple touch screen on the front panel. Data is quickly retrieved by USB key and can be analyzed for detailed pulse characteristics including pulse and pulse current.   -Pulse Agile® Advantage—transfection efficiency and cell viability are enhanced by specialized, programmable electrical pulse waveforms, particularly important for larger polynucleotide delivery such as DNA plasmids. The patented Pulse Agile technology combines a unique sequence of short high-intensity pulses to porate cell membranes, followed by long low-intensity pulses to further drive transfectants into cells via electrophoresis, while maintaining cell viability.  

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Patch-Clamp Amplifiers Axon

Introduction：
Patch-clamp amplifiers from single channels to large macroscopic recordings The Axon Instruments® series of amplifiers provide best-in-class solutions for the entire range of patch-clamp experiments. The portfolio of amplifiers includes Axopatch™ 200B for ultra low-noise single-channel recordings, MultiClamp™ 700B for whole-cell voltage-clamp and high-speed current-clamp recordings, and Axoclamp™ 900A for two-electrode voltage-clamp and current-clamp recordings.   Maximize signal to noise ratio The Axopatch 200B Capacitor Feedback Patch Clamp Amplifier offers one of the lowest-noise single-channel recordings available via innovative capacitor-feedback technology.   Perform multi-channel experiments The MultiClamp 700B Microelectrode Amplifier enables whole-cell voltage-clamp and current-clamp recordings. It is the most versatile amplifier in the portfolio.   Measure large currents Large output compliance range of our Axoclamp 900A Microelectrode Amplifier facilitates the measurement of large and rapid voltage-clamp and current-clamp recordings.   Actively cooled headstage The Axopatch 200B amplifier features proprietary technology that provides active headstage cooling that reduces electrical noise close to the theoretical limits of physics.   Software control of settings The MultiClamp 700B and Axoclamp 900A amplifiers offer software control. Software control streamlines setup, and enables automation of parameters, telegraphing, and advanced protocols.   Support up to four headstages The MultiClamp 700B supports up to two primary CV-7B headstages and two optional auxiliary headstages (HS-2 or VG-2 type) enabling multi-channel recording for cellular network studies.   Large output compliance range The Axoclamp 900A amplifier supports the measurement of larger currents and ensures faster clamp speed (±180 V in TEVC and HVIC modes).   Multiple modes of operation The Axoclamp 900A amplifier offers 5 modes of operation: current clamp, discontinuous current clamp, two-electrode voltage clamp, discontinuous single-electrode voltage clamp, high-voltage current clamp.   Works with any data acquisition system The family of amplifiers integrates with most data acquisition programs. The pCLAMP™ 11 Software and DigiData® 1550B system for data acquisition and analysis provide optimal performance.  

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Single-Cell Dispenser DispenCell

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A simple single-cell dispenser for proof of monoclonality The DispenCell™ Single-Cell Dispenser is an automated laboratory instrument designed for fast, easy and gentle single-cell isolation. DispenCell integrates seamlessly into your laboratory workflow, with a plug-and-play approach. Flexible and effortless, DispenCell operates equally under sterile conditions in a culture hood, or on a simple benchtop.   Immediate and traceable proof of clonality DispenSoft, the single-cell analysis software included with DispenCell, provides immediate and traceable proof of clonality. The instrument is fitted with a sensing tip that detects the passage of cells, allowing users to check for proof of clonality immediately after the cells are dispensed. All dispensing data is automatically stored, allowing for easy generation of a clonality report.   As gentle as manual pipetting DispenCell has unique technology which allows for extremely gentle handling of the cell sample. Cells are exposed to no more pressure than with manual pipetting (less than 0.2 psi). This allows the instrument to preserve cell viability and outgrowth while simultaneously increasing cell deposition efficiency.   Compact The small footprint of the DispenCell allows it to fit perfectly into any laboratory setting: under a hood to work under sterile conditions, on a bench top for routine seeding, or in a pre-existing automated workflow.   Proof of clonality A single-cell analysis software tool provides a traceable proof of clonality report instantly.   Contamination-free A patented disposable tip ensures clean isolation of single cells and no cross contamination. Certified free from animal products and cytotoxic material.   High cloning efficiency Unique design ensures gentle dispensing for better viability and cloning efficiency   Easy to use Easy to set up, and intuitive with a simple interface. No cleaning or calibration required.    

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CloneSelect Imager (CSI and CSI FL)

Introduction：
New for 2022, the CloneSelect Imager FL, a next-generation fluorescent imaging solution for the assurance of monoclonality and automated confluence across diverse cell types Demonstrating that cell lines are monoclonal – or that a gene was edited as expected – can be a time-consuming and highly-subjective process when relying on conventional technologies. The CloneSelect® Imager and CloneSelect® Imager FL are a high-throughput automated solutions for imaging and analyzing mammalian cells. Tracking the formation of a colony from a single cell is effortless as barcoded plates are tracked over time. Automated acquisition and analysis provides accurate, objective, and consistent results. With high-resolution white light imaging, the CloneSelect Imager provides automated confluence, monoclonality assurance and industry leading acquisition times with the ability to image a 96-well plate in under two minutes. The all new CloneSelect Imager FL features high contrast multichannel fluorescent and white light imaging that allows for accurate single cell detection and proof of monoclonality at day 0. Streamline your workflow with comparative confluence assays to identify and verify gene edits.   Demonstrated IND success The Monoclonality Report feature streamlines the creation of supporting documentation for regulatory agencies. Reports are automatically generated based on parameters you select. The Monoclonality Report is an audit-ready document that supports filing for an Investigational New Drug (IND) Application with the FDA. (21 CFR Part 312)   Multichannel imaging and automated confluence Algorithms are optimized for accurate cell detection and address varying cell types and conditions. Publication-ready high-resolution imaging provides automatic confluence analysis and monoclonality assurance.   Rapid single cell confirmation The imager delivers industry leading acquisition times, imaging a 96-well plate in as little as two minutes and can verify monoclonality from day zero with fluorescence.   White light and fluorescent imaging Image every well in every plate with rapid acquisition times with label-free white light. Multichannel fluorescence imaging provides additional confidence of monoclonality and comparative confluence assays (red vs green).   Data tools to accelerate research timelines The software automatically calculates confluence measurements and generates growth curves, heatmaps, and image montages. Measurements for every well are automatically tracked over time. Streamline multiple steps (imaging, sample tracking, data analysis and report generation) in the cell line development workflow for IND filing.   Quickly image a variety of plate formats and cell types Image a 96-well plate in under two minutes. Compatible with adherent or settled suspension cell types such as CHO, HEK, hybridomas, iPSCs, and many other cell types.   Intelligent analysis with easy-to-use software The software automatically calculates confluence for each imaging time point. Growth curve, image montage, total growth, and mean rate are generated automatically and are exportable. Guided software user interface allows for simple 1-hour training.   High-resolution images High-speed fluorescence and high-resolution white light imaging with accurate detection of single cells including debris. Image visualization and data tracking over multiple days.   Custom automation options* The Automation and Customization Team offers a variety of custom services from robotic plate loading to fully automated workstations with liquid handling and incubation. We have built out custom automated work cells with the CloneSelect Imager for iPSC workflows, full assay systems and drug toxicity and characterization research.  

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Mammalian Colony Picker ClonePix 2

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A complete solution for the automated screening and objective selection of high-value clones across diverse cell types. The ClonePix® 2 Mammalian Colony Picker is a fully automated system for selecting high-value clones used in antibody discovery and cell line development. Screen more clones in less time with monoclonal verification on day zero, then screen and identify for highest producers in weeks, not months. Hybridomas, CHO cells, stem cells and other cell types are imaged and selected based on user-defined parameters. Plate handling, barcode reading, and picking are fully integrated, and all data, including images, are saved for downstream analysis. The picker increases the probability of finding optimally produced cell lines and significantly reduces time and labor.   Automate antibody discovery and cell line development workflows ClonePix 2 picker is 10x faster than labor-intensive limiting dilution and FACS. Our sophisticated software and integrated robotics enable a screening speed of > 10,000 clones per day.   Select cells with desirable attributes with monoclonality assurance from day 0 Easily screen and select clones based on protein productivity, antigen-specificity, cell viability, and expression levels of tagged recombinant proteins.   Increase the probability of identifying high-value clones while eliminating or recovering unstable clones early Picking accuracy < 1 mm. Robotic picking reduces the risk of colony disturbance. Images of picked clones are stored with data.   Multiple detection methods White light identifies and measures clone morphology, size and proximity. Fluorescence indicates expression level and/or specificity. Up to five fluorescent filters are available for multiplexing.   Sterility maintenance A host of sterility features and options including a UV light process for sanitizing the interior of the instrument, as well as pin washing and halogen drying are standard.   Integrated plate storage Includes two storage stacks for source and destination plates, each with a capacity of 10 plates.   Discrete colony formation Semi-solid CloneMediaTM encourages single cells to grow into discreet colonies, and allows for ease of plating. The media allows for a higher density of clones to be screened.   Animal-free media and reagents Chemically defined and animal-free, CloneMedia cell-culture media, is optimized to increase productivity and aid in visualizing secreted antibodies when used with the CloneDetectTM detection agent.   Custom automation options* The Advanced Workflow Engineering Solutions Team can customize the monoclonality system and offer added services such as integrated verification of monoclonality.  

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Microbial Colony Pickers QPix

Introduction：
Automated microbial screening system capable of picking up to 3,000 colonies per hour The QPix® Microbial Colony Picker leverages best-in-class colony picking technology to alleviate bottlenecks and quickly, accurately, and efficiently screen through massive genetic libraries. The easy-to-use, intuitive software guides users through setting up colony picking runs where precision robotics pick the right colonies every time.. In addition to microbial screening, the system automates several sample preparation and plate handling processes such as transfer of bacterial liquid culture and plating on agar. Data is automatically recorded into the machine’s database, providing users with a complete audit trail and sample tracking, ensuring that no data is ever lost. Our modular, scalable series of colony pickers allows groups of all sizes to increase the accuracy and throughput of their workflow, while still allowing for future throughput growth.   Identify colonies with a desired phenotype The QPix colony pickers support a wide variety of microorganisms and multiple selection modalities, including fluorescence intensity, blue/white selection, size and proximity, and zone of inhibition.   Select colonies efficiently A suite of organism-specific pin and agar sensor ensure efficient picking. The system delivers a picking efficiency of >98%, allowing you to walkaway with confidence.   Maintain Sterility A host of sterility features are available including a UV light for sanitizing the interior of the instrument, as well as pin washing, and halogen drying of pins.   Organism-specific pins Different shape and picking area pins maximize efficiency for E. coli, phage, and yeast. Plating-specific pins ensure uniform distribution of liquid culture onto agar.   Multiple imaging modes Colonies can be picked based on pre-specified parameters using white light, fluorescence, and color. The use of filters enables applications such as blue-white colony screening.   Plating and Spreading Automated plating and streaking of 96 samples can be done in 30 minutes, providing greater walk-away time.   Replication, grid and hit picking Automated plate handling and tracking streamlines downstream assay and sample management. QPix colony pickers provides flexible plate replication, gridding, and hit-picking capabilities.   Agar sensing Ultrasonic agar height sensor detects differences in height resulting from variable pouring volume enabling maximum picking efficiency.   Scalable automation options* The QPix HT model is a robot compatible solution with a modular deck. The Advanced Workflow Engineering Solutions Team can tailor a colony picker with a variety of custom services.    

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