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Single-Cell Dispenser DispenCell

Introduction：
A simple single-cell dispenser for proof of monoclonality The DispenCell™ Single-Cell Dispenser is an automated laboratory instrument designed for fast, easy and gentle single-cell isolation. DispenCell integrates seamlessly into your laboratory workflow, with a plug-and-play approach. Flexible and effortless, DispenCell operates equally under sterile conditions in a culture hood, or on a simple benchtop.   Immediate and traceable proof of clonality DispenSoft, the single-cell analysis software included with DispenCell, provides immediate and traceable proof of clonality. The instrument is fitted with a sensing tip that detects the passage of cells, allowing users to check for proof of clonality immediately after the cells are dispensed. All dispensing data is automatically stored, allowing for easy generation of a clonality report.   As gentle as manual pipetting DispenCell has unique technology which allows for extremely gentle handling of the cell sample. Cells are exposed to no more pressure than with manual pipetting (less than 0.2 psi). This allows the instrument to preserve cell viability and outgrowth while simultaneously increasing cell deposition efficiency.   Compact The small footprint of the DispenCell allows it to fit perfectly into any laboratory setting: under a hood to work under sterile conditions, on a bench top for routine seeding, or in a pre-existing automated workflow.   Proof of clonality A single-cell analysis software tool provides a traceable proof of clonality report instantly.   Contamination-free A patented disposable tip ensures clean isolation of single cells and no cross contamination. Certified free from animal products and cytotoxic material.   High cloning efficiency Unique design ensures gentle dispensing for better viability and cloning efficiency   Easy to use Easy to set up, and intuitive with a simple interface. No cleaning or calibration required.    

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CloneSelect Imager (CSI and CSI FL)

Introduction：
New for 2022, the CloneSelect Imager FL, a next-generation fluorescent imaging solution for the assurance of monoclonality and automated confluence across diverse cell types Demonstrating that cell lines are monoclonal – or that a gene was edited as expected – can be a time-consuming and highly-subjective process when relying on conventional technologies. The CloneSelect® Imager and CloneSelect® Imager FL are a high-throughput automated solutions for imaging and analyzing mammalian cells. Tracking the formation of a colony from a single cell is effortless as barcoded plates are tracked over time. Automated acquisition and analysis provides accurate, objective, and consistent results. With high-resolution white light imaging, the CloneSelect Imager provides automated confluence, monoclonality assurance and industry leading acquisition times with the ability to image a 96-well plate in under two minutes. The all new CloneSelect Imager FL features high contrast multichannel fluorescent and white light imaging that allows for accurate single cell detection and proof of monoclonality at day 0. Streamline your workflow with comparative confluence assays to identify and verify gene edits.   Demonstrated IND success The Monoclonality Report feature streamlines the creation of supporting documentation for regulatory agencies. Reports are automatically generated based on parameters you select. The Monoclonality Report is an audit-ready document that supports filing for an Investigational New Drug (IND) Application with the FDA. (21 CFR Part 312)   Multichannel imaging and automated confluence Algorithms are optimized for accurate cell detection and address varying cell types and conditions. Publication-ready high-resolution imaging provides automatic confluence analysis and monoclonality assurance.   Rapid single cell confirmation The imager delivers industry leading acquisition times, imaging a 96-well plate in as little as two minutes and can verify monoclonality from day zero with fluorescence.   White light and fluorescent imaging Image every well in every plate with rapid acquisition times with label-free white light. Multichannel fluorescence imaging provides additional confidence of monoclonality and comparative confluence assays (red vs green).   Data tools to accelerate research timelines The software automatically calculates confluence measurements and generates growth curves, heatmaps, and image montages. Measurements for every well are automatically tracked over time. Streamline multiple steps (imaging, sample tracking, data analysis and report generation) in the cell line development workflow for IND filing.   Quickly image a variety of plate formats and cell types Image a 96-well plate in under two minutes. Compatible with adherent or settled suspension cell types such as CHO, HEK, hybridomas, iPSCs, and many other cell types.   Intelligent analysis with easy-to-use software The software automatically calculates confluence for each imaging time point. Growth curve, image montage, total growth, and mean rate are generated automatically and are exportable. Guided software user interface allows for simple 1-hour training.   High-resolution images High-speed fluorescence and high-resolution white light imaging with accurate detection of single cells including debris. Image visualization and data tracking over multiple days.   Custom automation options* The Automation and Customization Team offers a variety of custom services from robotic plate loading to fully automated workstations with liquid handling and incubation. We have built out custom automated work cells with the CloneSelect Imager for iPSC workflows, full assay systems and drug toxicity and characterization research.  

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Mammalian Colony Picker ClonePix 2

Introduction：
A complete solution for the automated screening and objective selection of high-value clones across diverse cell types. The ClonePix® 2 Mammalian Colony Picker is a fully automated system for selecting high-value clones used in antibody discovery and cell line development. Screen more clones in less time with monoclonal verification on day zero, then screen and identify for highest producers in weeks, not months. Hybridomas, CHO cells, stem cells and other cell types are imaged and selected based on user-defined parameters. Plate handling, barcode reading, and picking are fully integrated, and all data, including images, are saved for downstream analysis. The picker increases the probability of finding optimally produced cell lines and significantly reduces time and labor.   Automate antibody discovery and cell line development workflows ClonePix 2 picker is 10x faster than labor-intensive limiting dilution and FACS. Our sophisticated software and integrated robotics enable a screening speed of > 10,000 clones per day.   Select cells with desirable attributes with monoclonality assurance from day 0 Easily screen and select clones based on protein productivity, antigen-specificity, cell viability, and expression levels of tagged recombinant proteins.   Increase the probability of identifying high-value clones while eliminating or recovering unstable clones early Picking accuracy < 1 mm. Robotic picking reduces the risk of colony disturbance. Images of picked clones are stored with data.   Multiple detection methods White light identifies and measures clone morphology, size and proximity. Fluorescence indicates expression level and/or specificity. Up to five fluorescent filters are available for multiplexing.   Sterility maintenance A host of sterility features and options including a UV light process for sanitizing the interior of the instrument, as well as pin washing and halogen drying are standard.   Integrated plate storage Includes two storage stacks for source and destination plates, each with a capacity of 10 plates.   Discrete colony formation Semi-solid CloneMediaTM encourages single cells to grow into discreet colonies, and allows for ease of plating. The media allows for a higher density of clones to be screened.   Animal-free media and reagents Chemically defined and animal-free, CloneMedia cell-culture media, is optimized to increase productivity and aid in visualizing secreted antibodies when used with the CloneDetectTM detection agent.   Custom automation options* The Advanced Workflow Engineering Solutions Team can customize the monoclonality system and offer added services such as integrated verification of monoclonality.  

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Microbial Colony Pickers QPix

Introduction：
Automated microbial screening system capable of picking up to 3,000 colonies per hour The QPix® Microbial Colony Picker leverages best-in-class colony picking technology to alleviate bottlenecks and quickly, accurately, and efficiently screen through massive genetic libraries. The easy-to-use, intuitive software guides users through setting up colony picking runs where precision robotics pick the right colonies every time.. In addition to microbial screening, the system automates several sample preparation and plate handling processes such as transfer of bacterial liquid culture and plating on agar. Data is automatically recorded into the machine’s database, providing users with a complete audit trail and sample tracking, ensuring that no data is ever lost. Our modular, scalable series of colony pickers allows groups of all sizes to increase the accuracy and throughput of their workflow, while still allowing for future throughput growth.   Identify colonies with a desired phenotype The QPix colony pickers support a wide variety of microorganisms and multiple selection modalities, including fluorescence intensity, blue/white selection, size and proximity, and zone of inhibition.   Select colonies efficiently A suite of organism-specific pin and agar sensor ensure efficient picking. The system delivers a picking efficiency of >98%, allowing you to walkaway with confidence.   Maintain Sterility A host of sterility features are available including a UV light for sanitizing the interior of the instrument, as well as pin washing, and halogen drying of pins.   Organism-specific pins Different shape and picking area pins maximize efficiency for E. coli, phage, and yeast. Plating-specific pins ensure uniform distribution of liquid culture onto agar.   Multiple imaging modes Colonies can be picked based on pre-specified parameters using white light, fluorescence, and color. The use of filters enables applications such as blue-white colony screening.   Plating and Spreading Automated plating and streaking of 96 samples can be done in 30 minutes, providing greater walk-away time.   Replication, grid and hit picking Automated plate handling and tracking streamlines downstream assay and sample management. QPix colony pickers provides flexible plate replication, gridding, and hit-picking capabilities.   Agar sensing Ultrasonic agar height sensor detects differences in height resulting from variable pouring volume enabling maximum picking efficiency.   Scalable automation options* The QPix HT model is a robot compatible solution with a modular deck. The Advanced Workflow Engineering Solutions Team can tailor a colony picker with a variety of custom services.    

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